Assay Detail
Binding
CHEMBL2169034
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Inhibition of rat liver ACLY
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The lipogenesis pathway as a cancer target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.71 | 6.82 |
| IC50 | 2 | 5.86 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118715 | — | — | 1 | 6.82 |
| CHEMBL2165254 | — | — | 1 | 6.55 |
| CHEMBL2165261 | — | — | 1 | 6.16 |
| CHEMBL119628 | — | — | 1 | 6.00 |
| CHEMBL1214277 | PURPURONE | — | 1 | 5.16 |
| CHEMBL2165262 | — | — | 1 | 4.82 |
| CHEMBL2165252 | — | — | 1 | 4.75 |
| CHEMBL1627232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118715 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL2165254 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL2165261 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL119628 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1214277 | PURPURONE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2165262 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL2165252 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL1627232 | — | Ki | = | 250000.0 | nM | - |