Assay Detail
Functional
CHEMBL2169232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human C4-2B cells incubated for 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP C4-2B |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiandrogenic, maspin induction, and antiprostate cancer activities of tanshinone IIA and its novel derivatives with modification in ring A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.39 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165459 | — | — | 1 | 7.00 |
| CHEMBL2165454 | — | — | 1 | 7.00 |
| CHEMBL2165458 | — | — | 1 | 6.52 |
| CHEMBL2165456 | — | — | 1 | 6.40 |
| CHEMBL2165455 | — | — | 1 | 6.40 |
| CHEMBL187266 | TANSHINONE IIA | — | 1 | 6.40 |
| CHEMBL2165461 | — | — | 1 | 6.30 |
| CHEMBL2165457 | — | — | 1 | 6.16 |
| CHEMBL2165598 | — | — | 1 | 5.92 |
| CHEMBL2165460 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165459 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2165454 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2165458 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2165456 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2165455 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL187266 | TANSHINONE IIA | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2165461 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2165457 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2165598 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2165460 | — | IC50 | = | 1800.0 | nM | 5.75 |