Assay Detail
Binding
CHEMBL2169293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP17 expressed in Escherichia coli using progesterone substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.16 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254328 | ABIRATERONE | 3.0 | 1 | 7.14 |
| CHEMBL2163638 | — | — | 1 | 5.81 |
| CHEMBL2163639 | — | — | 1 | 5.54 |
| CHEMBL2163646 | — | — | 1 | - |
| CHEMBL2163641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254328 | ABIRATERONE | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2163638 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL2163639 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL2163646 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2163641 | — | IC50 | > | 5000.0 | nM | - |