Assay Detail
Binding
CHEMBL2172949
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Inhibition of Aurora B
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.66 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171127 | — | — | 1 | 7.24 |
| CHEMBL2171124 | — | — | 1 | 6.39 |
| CHEMBL2171128 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171127 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2171124 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL2171128 | — | IC50 | = | 457.0 | nM | 6.34 |