Assay Detail
Functional
CHEMBL2172998
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Vasodilatory activity in Wistar rat denuded thoracic aorta assessed as inhibition of L-phenylephrine-induced contraction
28
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 14 | - | - |
| EC50 | 14 | 5.65 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487821 | — | — | 2 | 6.55 |
| CHEMBL486462 | — | — | 2 | 6.48 |
| CHEMBL538375 | — | — | 2 | 6.29 |
| CHEMBL561563 | — | — | 2 | 6.21 |
| CHEMBL2170568 | — | — | 2 | 6.08 |
| CHEMBL2170567 | — | — | 2 | 5.82 |
| CHEMBL2170578 | — | — | 2 | 5.60 |
| CHEMBL1817841 | ABRUCOMSTAT | 1.0 | 2 | 5.40 |
| CHEMBL2170570 | — | — | 2 | 5.38 |
| CHEMBL549881 | — | — | 2 | 5.24 |
| CHEMBL541439 | — | — | 2 | 5.08 |
| CHEMBL2170569 | — | — | 2 | 5.05 |
| CHEMBL2170577 | — | — | 2 | 4.96 |
| CHEMBL361225 | — | — | 2 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487821 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL486462 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL538375 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL561563 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2170568 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2170567 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2170578 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1817841 | ABRUCOMSTAT | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2170570 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL549881 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL541439 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL2170569 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL2170577 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL361225 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL487821 | — | Inhibition | - | % | - | |
| CHEMBL486462 | — | Inhibition | - | % | - | |
| CHEMBL561563 | — | Inhibition | - | % | - | |
| CHEMBL538375 | — | Inhibition | - | % | - | |
| CHEMBL2170570 | — | Inhibition | - | % | - | |
| CHEMBL2170569 | — | Inhibition | - | % | - | |
| CHEMBL361225 | — | Inhibition | - | % | - | |
| CHEMBL549881 | — | Inhibition | - | % | - | |
| CHEMBL541439 | — | Inhibition | - | % | - | |
| CHEMBL2170568 | — | Inhibition | - | % | - | |
| CHEMBL2170567 | — | Inhibition | - | % | - | |
| CHEMBL1817841 | ABRUCOMSTAT | Inhibition | - | % | - | |
| CHEMBL2170578 | — | Inhibition | - | % | - | |
| CHEMBL2170577 | — | Inhibition | - | % | - |