Assay Detail
Binding
CHEMBL2173027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FAAH in rat brain homogenates pre-incubated for 10 mins before addition of [3H]anandamide and [3H]AEA substrates for 30 mins by liquid scintillation counting
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 4.69 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171276 | — | — | 1 | 5.54 |
| CHEMBL2171262 | — | — | 1 | 5.50 |
| CHEMBL2171273 | — | — | 1 | 5.34 |
| CHEMBL374646 | — | — | 1 | 5.32 |
| CHEMBL2171247 | — | — | 1 | 5.25 |
| CHEMBL2171259 | — | — | 1 | 5.08 |
| CHEMBL2171258 | — | — | 1 | 4.99 |
| CHEMBL2171242 | — | — | 1 | 4.97 |
| CHEMBL2171252 | — | — | 1 | 4.83 |
| CHEMBL2171255 | — | — | 1 | 4.81 |
| CHEMBL2171243 | — | — | 1 | 4.70 |
| CHEMBL2171274 | — | — | 1 | 4.66 |
| CHEMBL2171272 | — | — | 1 | 4.66 |
| CHEMBL2171256 | — | — | 1 | 4.63 |
| CHEMBL2171271 | — | — | 1 | 4.59 |
| CHEMBL2171265 | — | — | 1 | 4.57 |
| CHEMBL2171241 | — | — | 1 | 4.51 |
| CHEMBL2171269 | — | — | 1 | 4.50 |
| CHEMBL216986 | — | — | 1 | 4.49 |
| CHEMBL2171257 | — | — | 1 | 4.48 |
| CHEMBL2171261 | — | — | 1 | 4.30 |
| CHEMBL2171254 | — | — | 1 | 4.27 |
| CHEMBL2171244 | — | — | 1 | 4.22 |
| CHEMBL2171249 | — | — | 1 | 4.19 |
| CHEMBL596757 | — | — | 1 | 4.18 |
| CHEMBL1316 | CARPROFEN | 4.0 | 1 | 4.11 |
| CHEMBL2171246 | — | — | 1 | 4.07 |
| CHEMBL2171275 | — | — | 1 | - |
| CHEMBL2171268 | — | — | 1 | - |
| CHEMBL2171260 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171276 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2171262 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2171273 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL374646 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2171247 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2171259 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL2171258 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2171242 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL2171252 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL2171255 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL2171243 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL2171274 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL2171272 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2171256 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL2171271 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL2171265 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL2171241 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL2171269 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL216986 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL2171257 | — | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL2171261 | — | IC50 | = | 50300.0 | nM | 4.30 |
| CHEMBL2171254 | — | IC50 | = | 53200.0 | nM | 4.27 |
| CHEMBL2171244 | — | IC50 | = | 59600.0 | nM | 4.22 |
| CHEMBL2171249 | — | IC50 | = | 64200.0 | nM | 4.19 |
| CHEMBL596757 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL1316 | CARPROFEN | IC50 | = | 78600.0 | nM | 4.11 |
| CHEMBL2171246 | — | IC50 | = | 84800.0 | nM | 4.07 |
| CHEMBL521 | IBUPROFEN | IC50 | - | — | - | |
| CHEMBL2171253 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171251 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171250 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171248 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171245 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171270 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171267 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171266 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL2171264 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171263 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171260 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171268 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171275 | — | IC50 | > | 100000.0 | nM | - |