Assay Detail
Functional
CHEMBL2173084
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Cytotoxicity against human BJeH cells expressing wild type RAS after 48 hrs by alamar blue assay
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BJeH |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| LC50 | 10 | - | - |
| EC50 | 1 | 6.24 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1499544 | — | — | 1 | 6.24 |
| CHEMBL2171149 | — | — | 1 | - |
| CHEMBL2171339 | — | — | 1 | - |
| CHEMBL2171337 | — | — | 1 | - |
| CHEMBL2009640 | — | — | 1 | - |
| CHEMBL2171166 | — | — | 1 | - |
| CHEMBL2171161 | — | — | 1 | - |
| CHEMBL2171159 | — | — | 1 | - |
| CHEMBL2171156 | — | — | 1 | - |
| CHEMBL2171347 | — | — | 1 | - |
| CHEMBL2171344 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1499544 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2171149 | — | LC50 | = | 52600.0 | nM | - |
| CHEMBL2171339 | — | LC50 | = | 52900.0 | nM | - |
| CHEMBL2171337 | — | LC50 | = | 63200.0 | nM | - |
| CHEMBL2009640 | — | LC50 | = | 71700.0 | nM | - |
| CHEMBL2171166 | — | LC50 | = | 54300.0 | nM | - |
| CHEMBL2171161 | — | LC50 | = | 60660.0 | nM | - |
| CHEMBL2171159 | — | LC50 | = | 73500.0 | nM | - |
| CHEMBL2171156 | — | LC50 | = | 48300.0 | nM | - |
| CHEMBL2171347 | — | LC50 | = | 82600.0 | nM | - |
| CHEMBL2171344 | — | LC50 | = | 32200.0 | nM | - |