Assay Detail
Functional
CHEMBL2173085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human BJeLR cells expressing RAS G12V mutant after 48 hrs by alamar blue assay
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BJeLR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| LC50 | 16 | - | - |
| EC50 | 1 | 7.60 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1499544 | — | — | 1 | 7.60 |
| CHEMBL2171159 | — | — | 1 | - |
| CHEMBL2171149 | — | — | 1 | - |
| CHEMBL2171342 | — | — | 1 | - |
| CHEMBL2171339 | — | — | 1 | - |
| CHEMBL2171337 | — | — | 1 | - |
| CHEMBL2009640 | — | — | 1 | - |
| CHEMBL2171166 | — | — | 1 | - |
| CHEMBL2171165 | — | — | 1 | - |
| CHEMBL2171163 | — | — | 1 | - |
| CHEMBL2171156 | — | — | 1 | - |
| CHEMBL2171154 | — | — | 1 | - |
| CHEMBL2171348 | — | — | 1 | - |
| CHEMBL2171347 | — | — | 1 | - |
| CHEMBL2171345 | — | — | 1 | - |
| CHEMBL2171344 | — | — | 1 | - |
| CHEMBL2171164 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1499544 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2171159 | — | LC50 | = | 31600.0 | nM | - |
| CHEMBL2171149 | — | LC50 | = | 10200.0 | nM | - |
| CHEMBL2171342 | — | LC50 | = | 81300.0 | nM | - |
| CHEMBL2171339 | — | LC50 | = | 12900.0 | nM | - |
| CHEMBL2171337 | — | LC50 | = | 6300.0 | nM | - |
| CHEMBL2009640 | — | LC50 | = | 71700.0 | nM | - |
| CHEMBL2171166 | — | LC50 | = | 54300.0 | nM | - |
| CHEMBL2171165 | — | LC50 | = | 42700.0 | nM | - |
| CHEMBL2171163 | — | LC50 | = | 46700.0 | nM | - |
| CHEMBL2171156 | — | LC50 | = | 23400.0 | nM | - |
| CHEMBL2171154 | — | LC50 | = | 59800.0 | nM | - |
| CHEMBL2171348 | — | LC50 | = | 32400.0 | nM | - |
| CHEMBL2171347 | — | LC50 | = | 7800.0 | nM | - |
| CHEMBL2171345 | — | LC50 | = | 12900.0 | nM | - |
| CHEMBL2171344 | — | LC50 | = | 23300.0 | nM | - |
| CHEMBL2171164 | — | LC50 | = | 35200.0 | nM | - |