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Assay Detail

CHEMBL2173264

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive binding affinity to full length human SMYD2 amino acid 1 to 433 expressed in Escherichia coli BL21 (DE3) after 90 mins by radioactive filter-binding assay in presence of P53 peptide
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

N-lysine methyltransferase SMYD2 (CHEMBL2169716)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Oncoepigenomics: making histone lysine methylation count.
Decarlo D, Hadden MK.
Eur J Med Chem (2012) 56 : 179 -194
PubMed 22975593 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.52 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2169920 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2169920 Ki = 300.0 nM 6.52