Assay Detail
Binding
CHEMBL2173308
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Aurora B kinase-mediated histone H3 phosphorylation at Ser10 in human MDA-MB-468 cells after 2 hrs by Western blot analysis
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.00 | 6.00 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170590 | — | — | 1 | 6.00 |
| CHEMBL2170591 | — | — | 1 | 6.00 |
| CHEMBL2170404 | — | — | 1 | 6.00 |
| CHEMBL2170407 | — | — | 1 | 6.00 |
| CHEMBL2170418 | — | — | 1 | 6.00 |
| CHEMBL2170417 | — | — | 1 | - |
| CHEMBL2169893 | — | — | 1 | - |
| CHEMBL2170416 | — | — | 1 | - |
| CHEMBL2170415 | — | — | 1 | - |
| CHEMBL2170414 | — | — | 1 | - |
| CHEMBL2170413 | — | — | 1 | - |
| CHEMBL2170412 | — | — | 1 | - |
| CHEMBL2170411 | — | — | 1 | - |
| CHEMBL2170410 | — | — | 1 | - |
| CHEMBL2170409 | — | — | 1 | - |
| CHEMBL2170408 | — | — | 1 | - |
| CHEMBL2170406 | — | — | 1 | - |
| CHEMBL2170405 | — | — | 1 | - |
| CHEMBL2170442 | — | — | 1 | - |
| CHEMBL2170419 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170590 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2170591 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2170404 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2170407 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2170418 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2170417 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2169893 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2170416 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2170415 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2170414 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL2170413 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL2170412 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL2170411 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL2170410 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL2170409 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL2170408 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2170406 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2170405 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2170442 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL2170419 | — | Inhibition | - | % | - |