Assay Detail
Binding
CHEMBL2173309
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Inhibition of Aurora B by 33P minase hotspot assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.03 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170414 | — | — | 1 | 7.97 |
| CHEMBL2170411 | — | — | 1 | 7.59 |
| CHEMBL2170412 | — | — | 1 | 7.52 |
| CHEMBL2170592 | — | — | 1 | 7.51 |
| CHEMBL2170413 | — | — | 1 | 7.39 |
| CHEMBL2170419 | — | — | 1 | 7.37 |
| CHEMBL2170410 | — | — | 1 | 7.36 |
| CHEMBL2170442 | — | — | 1 | 7.30 |
| CHEMBL2170415 | — | — | 1 | 7.25 |
| CHEMBL2169893 | — | — | 1 | 7.08 |
| CHEMBL2170591 | — | — | 1 | 7.03 |
| CHEMBL2170418 | — | — | 1 | 6.97 |
| CHEMBL2170404 | — | — | 1 | 6.91 |
| CHEMBL2170406 | — | — | 1 | 6.76 |
| CHEMBL2170405 | — | — | 1 | 6.75 |
| CHEMBL2170409 | — | — | 1 | 6.71 |
| CHEMBL2170597 | — | — | 1 | 6.71 |
| CHEMBL2170416 | — | — | 1 | 6.65 |
| CHEMBL2170590 | — | — | 1 | 6.63 |
| CHEMBL2170407 | — | — | 1 | 6.44 |
| CHEMBL2170408 | — | — | 1 | 5.82 |
| CHEMBL2170417 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170414 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL2170411 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL2170412 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2170592 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2170413 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL2170419 | — | IC50 | = | 42.9 | nM | 7.37 |
| CHEMBL2170410 | — | IC50 | = | 43.3 | nM | 7.36 |
| CHEMBL2170442 | — | IC50 | = | 50.2 | nM | 7.30 |
| CHEMBL2170415 | — | IC50 | = | 56.6 | nM | 7.25 |
| CHEMBL2169893 | — | IC50 | = | 83.7 | nM | 7.08 |
| CHEMBL2170591 | — | IC50 | = | 93.9 | nM | 7.03 |
| CHEMBL2170418 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL2170404 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL2170406 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL2170405 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2170409 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL2170597 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL2170416 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL2170590 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL2170407 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL2170408 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL2170417 | — | IC50 | - | — | - |