Assay Detail
Binding
CHEMBL2173352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DOT1L using [3H]-SAM as substrate after 30 mins
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase, H3 lysine-79 specific (CHEMBL1795117) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Oncoepigenomics: making histone lysine methylation count.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.40 | 9.40 |
| Ki | 1 | 6.52 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2169919 | — | — | 2 | 9.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2169919 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2169919 | — | Ki | = | 300.0 | nM | 6.52 |