Assay Detail
Binding
CHEMBL2173409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SYK in human mast cell cultures assessed as reduction in Anti-IgG-stimulated FcgammaR-mediated leukotriene LTC4 production by fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of spleen tyrosine kinase (SYK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.31 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1235110 | — | — | 1 | 8.30 |
| CHEMBL475251 | R-406 | 2.0 | 1 | 7.39 |
| CHEMBL1229525 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1235110 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL475251 | R-406 | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1229525 | — | IC50 | = | 570.0 | nM | 6.24 |