Assay Detail
Functional
CHEMBL2173448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116 cells expressing wild type b-Raf and KRAS mutant
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Conformation-specific effects of Raf kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.44 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1197798 | — | — | 1 | 6.14 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.70 |
| CHEMBL477989 | SB590885 | — | 1 | 5.34 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 4.57 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | - |
| CHEMBL525191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1197798 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL477989 | SB590885 | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | > | 2000.0 | nM | - |
| CHEMBL525191 | — | IC50 | > | 20000.0 | nM | - |