Assay Detail
Functional
CHEMBL2173450
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Antiproliferative activity against human A375 cells expressing B-Raf V600E mutant and wild type Ras
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Conformation-specific effects of Raf kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.27 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 6.51 |
| CHEMBL1197798 | — | — | 1 | 6.51 |
| CHEMBL477989 | SB590885 | — | 1 | 6.43 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 6.30 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.62 |
| CHEMBL525191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1197798 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL477989 | SB590885 | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL525191 | — | IC50 | < | 500.0 | nM | - |