Assay Detail
Functional
CHEMBL2173502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the development of seven representative paradigms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.88 | 9.00 |
| IC50 | 3 | 8.91 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283950 | L-737126 | — | 1 | 9.00 |
| CHEMBL72335 | — | — | 1 | 8.96 |
| CHEMBL439757 | — | — | 1 | 8.85 |
| CHEMBL431798 | — | — | 1 | 6.75 |
| CHEMBL1630842 | BILR 355 | 2.0 | 1 | - |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283950 | L-737126 | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL72335 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL439757 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL431798 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1630842 | BILR 355 | EC50 | = | 0.00026 | ug.mL-1 | - |
| CHEMBL308954 | ETRAVIRINE | IC50 | < | 10.0 | nM | - |