Assay Detail
Functional
CHEMBL2173540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 infected in MT4 cells expressing CXCR4 assessed as inhibition of virus-induced cytopathic effect after 5 days
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.32 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311028 | PLERIXAFOR OCTAHYDROCHLORIDE | — | 1 | 8.70 |
| CHEMBL2170300 | — | — | 1 | 7.72 |
| CHEMBL2170444 | — | — | 1 | 6.90 |
| CHEMBL2170445 | — | — | 1 | 6.89 |
| CHEMBL2170299 | — | — | 1 | 6.86 |
| CHEMBL2170443 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311028 | PLERIXAFOR OCTAHYDROCHLORIDE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2170300 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2170444 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL2170445 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2170299 | — | EC50 | = | 139.0 | nM | 6.86 |
| CHEMBL2170443 | — | EC50 | = | 137.0 | nM | 6.86 |