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Assay Detail

CHEMBL2173907

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human recombinant 5HT1A receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Mitigating heterocycle metabolism in drug discovery.
St Jean DJ, Fotsch C.
J Med Chem (2012) 55 : 6002 -6020
PubMed 22533875 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 3 8.99 9.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL300739 1 9.07
CHEMBL300100 1 8.90
CHEMBL51457 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL300739 Ki = 0.8511 nM 9.07
CHEMBL300100 Ki = 1.259 nM 8.90
CHEMBL51457 Ki = 436515832.24 nM -