Assay Detail
Functional
CHEMBL2174096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxant activity in rat aortic rings assessed as reduction of norepinephrine-induced contraction
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.46 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6622 | ISOSORBIDE DINITRATE | 4.0 | 1 | 4.60 |
| CHEMBL2171314 | — | — | 1 | 4.46 |
| CHEMBL2171333 | — | — | 1 | 4.31 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | - |
| CHEMBL2171308 | — | — | 1 | - |
| CHEMBL2171325 | — | — | 1 | - |
| CHEMBL255502 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6622 | ISOSORBIDE DINITRATE | EC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL2171314 | — | EC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL2171333 | — | EC50 | = | 48800.0 | nM | 4.31 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | EC50 | = | 1492800.0 | nM | - |
| CHEMBL2171308 | — | EC50 | = | 837500.0 | nM | - |
| CHEMBL2171325 | — | EC50 | = | 234400.0 | nM | - |
| CHEMBL255502 | — | EC50 | = | 2051200.0 | nM | - |