Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2174203

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLaS3 cells after 24 to 72 hrs by MTT assay
ChEMBL ↗
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa S3
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Structure-activity relationship in the antitumor activity of 6-, 8- or 6,8-substituted 3-benzylamino-β-carboline derivatives.
Ikeda R, Kimura T, Tsutsumi T, Tamura S, Sakai N, Konakahara T.
Bioorg Med Chem Lett (2012) 22 : 3506 -3515
PubMed 22520257 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 51 5.44 7.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2171525 — — 1 7.50
CHEMBL2171335 — — 1 7.34
CHEMBL1808759 — — 1 7.13
CHEMBL56459 — — 1 6.96
CHEMBL2171524 — — 1 6.85
CHEMBL2171568 — — 1 6.70
CHEMBL78464 — — 1 6.70
CHEMBL2171569 — — 1 6.57
CHEMBL2171558 — — 1 6.00
CHEMBL2171536 — — 1 5.96
CHEMBL2171540 — — 1 5.92
CHEMBL2171541 — — 1 5.85
CHEMBL2171539 — — 1 5.82
CHEMBL2171546 — — 1 5.75
CHEMBL2171559 — — 1 5.67
CHEMBL2171537 — — 1 5.58
CHEMBL2171556 — — 1 5.58
CHEMBL2171545 — — 1 5.55
CHEMBL2171570 — — 1 5.54
CHEMBL2171532 — — 1 5.47
CHEMBL2171561 — — 1 5.43
CHEMBL2171542 — — 1 5.42
CHEMBL2171543 — — 1 5.38
CHEMBL2171538 — — 1 5.38
CHEMBL2171560 — — 1 5.34
CHEMBL2171548 — — 1 5.32
CHEMBL2171567 — — 1 5.21
CHEMBL2171564 — — 1 5.20
CHEMBL2171566 — — 1 5.16
CHEMBL2171547 — — 1 5.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2171525 — IC50 = 32.0 nM 7.50
CHEMBL2171335 — IC50 = 46.0 nM 7.34
CHEMBL1808759 — IC50 = 74.0 nM 7.13
CHEMBL56459 — IC50 = 110.0 nM 6.96
CHEMBL2171524 — IC50 = 141.0 nM 6.85
CHEMBL2171568 — IC50 = 200.0 nM 6.70
CHEMBL78464 — IC50 = 200.0 nM 6.70
CHEMBL2171569 — IC50 = 270.0 nM 6.57
CHEMBL2171558 — IC50 = 990.0 nM 6.00
CHEMBL2171536 — IC50 = 1100.0 nM 5.96
CHEMBL2171540 — IC50 = 1200.0 nM 5.92
CHEMBL2171541 — IC50 = 1400.0 nM 5.85
CHEMBL2171539 — IC50 = 1500.0 nM 5.82
CHEMBL2171546 — IC50 = 1800.0 nM 5.75
CHEMBL2171559 — IC50 = 2130.0 nM 5.67
CHEMBL2171537 — IC50 = 2600.0 nM 5.58
CHEMBL2171556 — IC50 = 2600.0 nM 5.58
CHEMBL2171545 — IC50 = 2800.0 nM 5.55
CHEMBL2171570 — IC50 = 2900.0 nM 5.54
CHEMBL2171532 — IC50 = 3400.0 nM 5.47
CHEMBL2171561 — IC50 = 3700.0 nM 5.43
CHEMBL2171542 — IC50 = 3800.0 nM 5.42
CHEMBL2171543 — IC50 = 4200.0 nM 5.38
CHEMBL2171538 — IC50 = 4200.0 nM 5.38
CHEMBL2171560 — IC50 = 4600.0 nM 5.34
CHEMBL2171548 — IC50 = 4840.0 nM 5.32
CHEMBL2171567 — IC50 = 6090.0 nM 5.21
CHEMBL2171564 — IC50 = 6300.0 nM 5.20
CHEMBL2171566 — IC50 = 7000.0 nM 5.16
CHEMBL2171547 — IC50 = 8000.0 nM 5.10
CHEMBL2171557 — IC50 = 9000.0 nM 5.05
CHEMBL2171565 — IC50 = 9200.0 nM 5.04
CHEMBL2171535 — IC50 = 10000.0 nM 5.00
CHEMBL2171555 — IC50 = 9900.0 nM 5.00
CHEMBL2171534 — IC50 = 10000.0 nM 5.00
CHEMBL2171528 — IC50 = 11000.0 nM 4.96
CHEMBL2171553 — IC50 = 12000.0 nM 4.92
CHEMBL2171563 — IC50 = 13000.0 nM 4.89
CHEMBL2171533 — IC50 = 14000.0 nM 4.85
CHEMBL2171530 — IC50 = 15000.0 nM 4.82
CHEMBL2171562 — IC50 = 15000.0 nM 4.82
CHEMBL2171531 — IC50 = 19000.0 nM 4.72
CHEMBL2171554 — IC50 = 21000.0 nM 4.68
CHEMBL2171529 — IC50 = 21000.0 nM 4.68
CHEMBL2171549 — IC50 = 26100.0 nM 4.58
CHEMBL2171551 — IC50 = 27000.0 nM 4.57
CHEMBL2171527 — IC50 = 28000.0 nM 4.55
CHEMBL2171552 — IC50 = 56000.0 nM 4.25
CHEMBL54381 — IC50 = 66000.0 nM 4.18
CHEMBL2171544 — IC50 = 71000.0 nM 4.15