Assay Detail
Binding
CHEMBL2174308
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Inhibition of recombinant human myeloperoxidase assessed as taurine chloramine production after 5 mins by spectrophotometry in presence of H2O2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Urine |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of new scaffolds of myeloperoxidase inhibitors by rational design combined with high-throughput virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.64 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170247 | — | — | 1 | 6.34 |
| CHEMBL1370773 | — | — | 1 | 6.30 |
| CHEMBL2170246 | — | — | 1 | 6.01 |
| CHEMBL2170248 | — | — | 1 | 5.46 |
| CHEMBL2170244 | — | — | 1 | 5.43 |
| CHEMBL2170245 | — | — | 1 | 5.42 |
| CHEMBL1405583 | — | — | 1 | 5.21 |
| CHEMBL2002487 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170247 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1370773 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2170246 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL2170248 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2170244 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2170245 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1405583 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2002487 | — | IC50 | = | 12000.0 | nM | 4.92 |