Assay Detail
Functional
CHEMBL2174476
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Vasodilatory activity in Wistar rat thoracic aorta assessed as relaxation of L-phenylephrine-induced contraction after 120 mins
13
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 7 | - | - |
| EC50 | 6 | 6.70 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171725 | — | — | 2 | 8.62 |
| CHEMBL2171728 | — | — | 2 | 8.00 |
| CHEMBL2171727 | — | — | 2 | 6.13 |
| CHEMBL2171724 | — | — | 2 | 6.05 |
| CHEMBL782 | TOLBUTAMIDE | 4.0 | 2 | 5.80 |
| CHEMBL2171726 | — | — | 2 | 5.62 |
| CHEMBL2171729 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171725 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2171728 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2171727 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL2171724 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL782 | TOLBUTAMIDE | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2171726 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2171728 | — | Activity | - | — | - | |
| CHEMBL2171727 | — | Activity | - | — | - | |
| CHEMBL2171726 | — | Activity | - | — | - | |
| CHEMBL2171725 | — | Activity | - | — | - | |
| CHEMBL2171724 | — | Activity | - | — | - | |
| CHEMBL782 | TOLBUTAMIDE | Activity | - | — | - | |
| CHEMBL2171729 | — | Activity | - | — | - |