Assay Detail
Functional
CHEMBL2174477
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Vasodilatory activity in Wistar rat thoracic aorta assessed as relaxation of L-phenylephrine-induced contraction after 120 mins in presence of 1 uM sGC inhibitor ODQ
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.29 | 6.66 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171726 | — | — | 1 | 6.66 |
| CHEMBL2171729 | — | — | 1 | 6.05 |
| CHEMBL2171728 | — | — | 1 | 4.24 |
| CHEMBL2171725 | — | — | 1 | 4.21 |
| CHEMBL2171727 | — | — | 1 | - |
| CHEMBL2171724 | — | — | 1 | - |
| CHEMBL782 | TOLBUTAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171726 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2171729 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2171728 | — | EC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL2171725 | — | EC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL2171727 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2171724 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL782 | TOLBUTAMIDE | Activity | - | — | - |