Assay Detail
Functional
CHEMBL2174484
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Antiaggregatory activity in human platelet-rich plasma assessed as inhibition of collagen-induced aggregation pretreated 10 mins before addition of stimulus measured after 10 mins in presence of 50 uM ODQ
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.73 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171725 | — | — | 1 | 5.05 |
| CHEMBL2171728 | — | — | 1 | 4.66 |
| CHEMBL2171726 | — | — | 1 | 4.47 |
| CHEMBL2171729 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171725 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL2171728 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2171726 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL2171729 | — | IC50 | = | 209000.0 | nM | - |