Assay Detail
Binding
CHEMBL2175126
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant cathepsin-S using Z-Val-Val-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.84 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171995 | — | — | 1 | 6.26 |
| CHEMBL2169908 | — | — | 1 | 6.09 |
| CHEMBL2164676 | — | — | 1 | 5.99 |
| CHEMBL2171986 | — | — | 1 | 5.98 |
| CHEMBL2172002 | — | — | 1 | 5.96 |
| CHEMBL2171988 | — | — | 1 | 5.96 |
| CHEMBL2172004 | — | — | 1 | 5.94 |
| CHEMBL2171999 | — | — | 1 | 5.91 |
| CHEMBL2172006 | — | — | 1 | 5.91 |
| CHEMBL2172000 | — | — | 1 | 5.90 |
| CHEMBL2172007 | — | — | 1 | 5.89 |
| CHEMBL2171990 | — | — | 1 | 5.89 |
| CHEMBL2070936 | — | — | 1 | 5.88 |
| CHEMBL2172003 | — | — | 1 | 5.86 |
| CHEMBL2172005 | — | — | 1 | 5.84 |
| CHEMBL2171996 | — | — | 1 | 5.82 |
| CHEMBL2171984 | — | — | 1 | 5.78 |
| CHEMBL2172001 | — | — | 1 | 5.76 |
| CHEMBL2171994 | — | — | 1 | 5.67 |
| CHEMBL2171991 | — | — | 1 | 5.65 |
| CHEMBL2171993 | — | — | 1 | 5.64 |
| CHEMBL2171989 | — | — | 1 | 5.58 |
| CHEMBL2171992 | — | — | 1 | 5.53 |
| CHEMBL2172126 | — | — | 1 | 5.43 |
| CHEMBL2171998 | — | — | 1 | - |
| CHEMBL2171997 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171995 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL2169908 | — | IC50 | = | 807.0 | nM | 6.09 |
| CHEMBL2164676 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL2171986 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL2172002 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2171988 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL2172004 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL2171999 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL2172006 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL2172000 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL2172007 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2171990 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL2070936 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL2172003 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL2172005 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL2171996 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL2171984 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL2172001 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL2171994 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL2171991 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL2171993 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL2171989 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2171992 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL2172126 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL2171998 | — | IC50 | > | 7430.0 | nM | - |
| CHEMBL2171997 | — | IC50 | > | 11800.0 | nM | - |