Assay Detail
Binding
CHEMBL2175127
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cathepsin-k
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.88 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371064 | BALICATIB | 2.0 | 1 | 8.30 |
| CHEMBL2070936 | — | — | 1 | 7.82 |
| CHEMBL2071097 | — | — | 1 | 7.52 |
| CHEMBL2163587 | — | — | 1 | - |
| CHEMBL481611 | ODANACATIB | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371064 | BALICATIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2070936 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2071097 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2163587 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL481611 | ODANACATIB | IC50 | < | 1.0 | nM | - |