Assay Detail
ADMET
CHEMBL2175147
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Cytotoxicity against rat L6 cells incubated for 690 hrs by Alamar blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of antischistosomal leads by evaluating bridged 1,2,4,5-tetraoxanes, alphaperoxides, and tricyclic monoperoxides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.08 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 5.82 |
| CHEMBL2170507 | — | — | 1 | 5.77 |
| CHEMBL2170514 | — | — | 1 | 5.66 |
| CHEMBL2170331 | — | — | 1 | 5.09 |
| CHEMBL2170337 | — | — | 1 | 4.99 |
| CHEMBL2170339 | — | — | 1 | 4.23 |
| CHEMBL2170362 | — | — | 1 | 4.00 |
| CHEMBL976 | PRAZIQUANTEL | 4.0 | 1 | - |
| CHEMBL2170335 | — | — | 1 | - |
| CHEMBL2170333 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2170507 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2170514 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2170331 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL2170337 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL2170339 | — | IC50 | = | 58300.0 | nM | 4.23 |
| CHEMBL2170362 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL976 | PRAZIQUANTEL | IC50 | > | 96000.0 | nM | - |
| CHEMBL2170335 | — | IC50 | > | 93000.0 | nM | - |
| CHEMBL2170333 | — | IC50 | > | 103000.0 | nM | - |