Assay Detail
Binding
CHEMBL2175175
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Inhibition of recombinant STAT3 assessed as inhibition of STAT3-phosphododecapeptide interaction by SPR analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.61 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2031566 | — | — | 1 | 4.70 |
| CHEMBL2172008 | — | — | 1 | 4.52 |
| CHEMBL2172009 | — | — | 1 | - |
| CHEMBL2171900 | — | — | 1 | - |
| CHEMBL2171899 | — | — | 1 | - |
| CHEMBL2171898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2031566 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2172008 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2172009 | — | IC50 | = | 114000.0 | nM | - |
| CHEMBL2171900 | — | IC50 | = | 137000.0 | nM | - |
| CHEMBL2171899 | — | IC50 | = | 256000.0 | nM | - |
| CHEMBL2171898 | — | IC50 | = | 447000.0 | nM | - |