Assay Detail
Binding
CHEMBL2175186
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction after 15 mins by fluorescence polarization assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.57 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1829786 | — | — | 1 | 4.82 |
| CHEMBL2023986 | — | — | 1 | 4.78 |
| CHEMBL2172014 | — | — | 1 | 4.73 |
| CHEMBL2023987 | — | — | 1 | 4.67 |
| CHEMBL2172013 | — | — | 1 | 4.30 |
| CHEMBL477936 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1829786 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL2023986 | — | Ki | = | 16700.0 | nM | 4.78 |
| CHEMBL2172014 | — | Ki | = | 18700.0 | nM | 4.73 |
| CHEMBL2023987 | — | Ki | = | 21500.0 | nM | 4.67 |
| CHEMBL2172013 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL477936 | — | Ki | = | 80000.0 | nM | 4.10 |