Assay Detail
Binding
CHEMBL2175247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-AVP from human oxytocin receptor expressed in CHO cells after 30 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective fluorescent nonpeptidic antagonists for vasopressin V₂ GPCR: application to ligand screening and oligomerization assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.79 | 8.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | 8.78 |
| CHEMBL603708 | — | — | 1 | 6.96 |
| CHEMBL2172289 | — | — | 1 | 6.74 |
| CHEMBL2172292 | — | — | 1 | 6.51 |
| CHEMBL2172293 | — | — | 1 | 6.30 |
| CHEMBL2172288 | — | — | 1 | 6.18 |
| CHEMBL2172290 | — | — | 1 | 6.09 |
| CHEMBL2172295 | — | — | 1 | - |
| CHEMBL2172294 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373742 | VASOPRESSIN | Ki | = | 1.65 | nM | 8.78 |
| CHEMBL603708 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL2172289 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL2172292 | — | Ki | = | 307.0 | nM | 6.51 |
| CHEMBL2172293 | — | Ki | = | 495.0 | nM | 6.30 |
| CHEMBL2172288 | — | Ki | = | 665.0 | nM | 6.18 |
| CHEMBL2172290 | — | Ki | = | 808.0 | nM | 6.09 |
| CHEMBL2172295 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2172294 | — | Ki | > | 10000.0 | nM | - |