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Assay Detail

CHEMBL2175398

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimicrobial activity against SSG-resistant Leishmania donovani 39 amastigote infected in mouse peritoneal macrophages assessed as inhibition of parasite growth after 72 hrs by Giemsa staining method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Flavonoid dimers as novel, potent antileishmanial agents.
Wong IL, Chan KF, Chan TH, Chow LM.
J Med Chem (2012) 55 : 8891 -8902
PubMed 22989363 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.45 7.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267345 AMPHOTERICIN B 4.0 1 7.21
CHEMBL2172401 1 6.20
CHEMBL2172424 1 5.85
CHEMBL2172414 1 5.64
CHEMBL2172420 1 5.62
CHEMBL2172419 1 5.51
CHEMBL2172416 1 5.51
CHEMBL2172402 1 5.39
CHEMBL2172418 1 5.28
CHEMBL2172413 1 5.24
CHEMBL50 QUERCETIN 3.0 1 5.22
CHEMBL2172415 1 5.16
CHEMBL2172422 1 5.12
CHEMBL151 LUTEOLIN 2.0 1 5.11
CHEMBL125 MILTEFOSINE 4.0 1 4.80
CHEMBL370143 PAROMOMYCIN 4.0 1 4.39
CHEMBL2079699 1 -
CHEMBL2172423 1 -
CHEMBL55 PENTAMIDINE 4.0 1 -
CHEMBL2172421 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267345 AMPHOTERICIN B IC50 = 62.0 nM 7.21
CHEMBL2172401 IC50 = 630.0 nM 6.20
CHEMBL2172424 IC50 = 1400.0 nM 5.85
CHEMBL2172414 IC50 = 2300.0 nM 5.64
CHEMBL2172420 IC50 = 2400.0 nM 5.62
CHEMBL2172419 IC50 = 3100.0 nM 5.51
CHEMBL2172416 IC50 = 3100.0 nM 5.51
CHEMBL2172402 IC50 = 4100.0 nM 5.39
CHEMBL2172418 IC50 = 5200.0 nM 5.28
CHEMBL2172413 IC50 = 5800.0 nM 5.24
CHEMBL50 QUERCETIN IC50 = 6000.0 nM 5.22
CHEMBL2172415 IC50 = 7000.0 nM 5.16
CHEMBL2172422 IC50 = 7600.0 nM 5.12
CHEMBL151 LUTEOLIN IC50 = 7700.0 nM 5.11
CHEMBL125 MILTEFOSINE IC50 = 16000.0 nM 4.80
CHEMBL370143 PAROMOMYCIN IC50 = 41000.0 nM 4.39
CHEMBL2079699 IC50 = 675000.0 nM -
CHEMBL2172423 IC50 > 7600.0 nM -
CHEMBL55 PENTAMIDINE IC50 > 30000.0 nM -
CHEMBL2172421 IC50 > 10000.0 nM -