Assay Detail
Binding
CHEMBL2175753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE4C
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4C (CHEMBL291) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.96 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172710 | — | — | 1 | 6.69 |
| CHEMBL2172734 | — | — | 1 | 6.30 |
| CHEMBL2172707 | — | — | 1 | 5.43 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172710 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL2172734 | — | IC50 | = | 505.0 | nM | 6.30 |
| CHEMBL2172707 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 3690.0 | nM | 5.43 |