3',5'-cyclic-AMP phosphodiesterase 4C · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q08493. Use UniProt Q08493 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q08493 as the stable identity anchor, then attach disease evidence before program review.
3',5'-cyclic-AMP phosphodiesterase 4C
Review this target as 3',5'-cyclic-AMP phosphodiesterase 4C, mapped to UniProt Q08493. Sequence length is 712 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 3',5'-cyclic-AMP phosphodiesterase 4C as ChEMBL target CHEMBL291, mapped to UniProt Q08493. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 3',5'-cyclic-AMP phosphodiesterase 4C is the right protein anchor across sources, using UniProt Q08493 as the stable mapping.
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| Preferred Name | 3',5'-cyclic-AMP phosphodiesterase 4C |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q08493 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3',5'-cyclic-AMP phosphodiesterase 4C |
| UniProt Accession | Q08493 |
| Component Type | Protein |
| Sequence Length | 712 aa |
3',5'-cyclic-AMP phosphodiesterase 4C
Review this target as 3',5'-cyclic-AMP phosphodiesterase 4C, mapped to UniProt Q08493. Sequence length is 712 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5417689 | 10.6 | IC50 | 0.02512 | Preclinical |
| CHEMBL380321 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL197392 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL198674 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL196969 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL206968 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL199015 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL383225 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL381681 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL193240 | 8.77 | IC50 | 1.7 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 42 | 153 | 7.0 |
| assay format | 8 | 154 | 6.9 |
| cell-based format | 5 | 9 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 3 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 0 | — |
| cell-based format | 1 | 0 | — |