Compound Detail
CHEMBL197392
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Cc1ccc(/C(=C/c2cccc(-c3cc(C(C)C)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)nc1
Basic Information
| ChEMBL ID | CHEMBL197392 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IJGHHSIAVWWRGI-UXHLAJHPSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
518.7
MW (Da)
7.72
ALogP
4
HBA
0
HBD
59.9
PSA (Ų)
0.22
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 4 CHEMBL2093863 | IC50 | 9.92 | 9.92 | 0.1 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4A CHEMBL254 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4C CHEMBL291 | IC50 | 9.4 | 9.4 | 0.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 4 | IC50 | = | 0.12 | nM | 9.92 | Inhibition of LPS-induced TNFalpha production in human whole blood | 16168647 |
| 3',5'-cyclic-AMP phosphodiesterase 4A | IC50 | = | 0.2 | nM | 9.7 | Inhibitory activity against PDE4A | 16168647 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 0.2 | nM | 9.7 | Inhibitory activity against PDE4B | 16168647 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 0.2 | nM | 9.7 | Inhibitory activity against PDE4D | 16168647 |
| 3',5'-cyclic-AMP phosphodiesterase 4C | IC50 | = | 0.4 | nM | 9.4 | Inhibitory activity against PDE4C | 16168647 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16168647 | 10.1016/j.bmcl.2005.08.036 | 3',5'-cyclic-AMP phosphodiesterase 4A | 1 |
| 16168647 | 10.1016/j.bmcl.2005.08.036 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 16168647 | 10.1016/j.bmcl.2005.08.036 | 3',5'-cyclic-AMP phosphodiesterase 4C | 1 |
| 16168647 | 10.1016/j.bmcl.2005.08.036 | 3',5'-cyclic-AMP phosphodiesterase 4D | 1 |
| 16168647 | 10.1016/j.bmcl.2005.08.036 | Phosphodiesterase 4 | 1 |
Data from ChEMBL 36 via Core Engine