Assay Detail
Binding
CHEMBL860122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against PDE4D
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.91 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196969 | — | — | 1 | 9.72 |
| CHEMBL197392 | — | — | 1 | 9.70 |
| CHEMBL381681 | — | — | 1 | 9.70 |
| CHEMBL199015 | — | — | 1 | 9.40 |
| CHEMBL198674 | — | — | 1 | 9.30 |
| CHEMBL197386 | — | — | 1 | 9.30 |
| CHEMBL198853 | — | — | 1 | 9.30 |
| CHEMBL371089 | — | — | 1 | 9.22 |
| CHEMBL197494 | — | — | 1 | 9.22 |
| CHEMBL371037 | — | — | 1 | 9.15 |
| CHEMBL372575 | — | — | 1 | 8.92 |
| CHEMBL198732 | — | — | 1 | 8.72 |
| CHEMBL370220 | — | — | 1 | 8.70 |
| CHEMBL198722 | — | — | 1 | 8.70 |
| CHEMBL32442 | CDP840 | — | 1 | 8.68 |
| CHEMBL198527 | — | — | 1 | 8.64 |
| CHEMBL198432 | — | — | 1 | 8.60 |
| CHEMBL198564 | — | — | 1 | 8.36 |
| CHEMBL382545 | — | — | 1 | 7.42 |
| CHEMBL198464 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196969 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL197392 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL381681 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL199015 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL198674 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL197386 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL198853 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL371089 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL197494 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL371037 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL372575 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL198732 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL370220 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL198722 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL32442 | CDP840 | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL198527 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL198432 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL198564 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL382545 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL198464 | — | IC50 | = | 45.0 | nM | 7.35 |