Assay Detail
Binding
CHEMBL2175754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE4B
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.97 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172710 | — | — | 1 | 7.33 |
| CHEMBL2172734 | — | — | 1 | 7.28 |
| CHEMBL2172707 | — | — | 1 | 6.64 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172710 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2172734 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2172707 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 231.0 | nM | 6.64 |