Assay Detail
Binding
CHEMBL2175827
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Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 24 hrs GC/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A new class of selective and potent 7-dehydrocholesterol reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.75 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172347 | — | — | 1 | 8.64 |
| CHEMBL2172349 | — | — | 1 | 6.92 |
| CHEMBL2172263 | — | — | 1 | 6.30 |
| CHEMBL2172350 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172347 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2172349 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2172263 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2172350 | — | IC50 | = | 7300.0 | nM | 5.14 |