Assay Detail
Functional
CHEMBL2176059
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Induction of ABCA1 mRNA expression in human HuH7 cells after 24 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22373 | CL-976 | — | 1 | 6.22 |
| CHEMBL2170728 | — | — | 1 | 6.22 |
| CHEMBL2170736 | — | — | 1 | 6.22 |
| CHEMBL520938 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22373 | CL-976 | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2170728 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2170736 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL520938 | — | EC50 | = | 600.0 | nM | 6.22 |