Assay Detail
Binding
CHEMBL2176154
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Inhibition of ACAT activity in human MC65 cells using NBD-cholesterol staining after 48 hrs by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MC65 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.14 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22373 | CL-976 | — | 1 | 6.70 |
| CHEMBL2170736 | — | — | 1 | 6.52 |
| CHEMBL2170728 | — | — | 1 | 6.10 |
| CHEMBL520938 | — | — | 1 | 5.92 |
| CHEMBL2170821 | — | — | 1 | 5.85 |
| CHEMBL2170832 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22373 | CL-976 | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2170736 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2170728 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL520938 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2170821 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2170832 | — | IC50 | = | 1800.0 | nM | 5.75 |