Assay Detail
Binding
CHEMBL2176221
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AGT in human HL60 cells assessed as AGT levels using [3H]AGT after 2 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Methylated-DNA--protein-cysteine methyltransferase (CHEMBL2864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.53 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485756 | — | — | 1 | 8.05 |
| CHEMBL2171205 | — | — | 1 | 7.60 |
| CHEMBL407874 | 6-O-BENZYLGUANINE | 3.0 | 1 | 7.41 |
| CHEMBL2171202 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485756 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2171205 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL407874 | 6-O-BENZYLGUANINE | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2171202 | — | IC50 | = | 86.0 | nM | 7.07 |