Assay Detail
Binding
CHEMBL2176370
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-Met enzyme
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.26 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172324 | — | — | 1 | 5.29 |
| CHEMBL2172322 | — | — | 1 | 5.23 |
| CHEMBL2172323 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172324 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL2172322 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL2172323 | — | IC50 | - | — | - |