Assay Detail
Binding
CHEMBL2176391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat histidine tagged FAAH expressed in Escherichia coli by coumarin ester substrate fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Assay and inhibition of diacylglycerol lipase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.04 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184238 | URB-597 | 1.0 | 1 | 8.31 |
| CHEMBL94809 | HEXADECANESULFONYL FLUORIDE | — | 1 | 8.20 |
| CHEMBL175247 | ORLISTAT | 4.0 | 1 | 8.00 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | — | 1 | 6.08 |
| CHEMBL576786 | — | — | 1 | 6.01 |
| CHEMBL158897 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184238 | URB-597 | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL94809 | HEXADECANESULFONYL FLUORIDE | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL175247 | ORLISTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | IC50 | = | 833.0 | nM | 6.08 |
| CHEMBL576786 | — | IC50 | = | 974.0 | nM | 6.01 |
| CHEMBL158897 | — | IC50 | = | 2240.0 | nM | 5.65 |