Assay Detail
Functional
CHEMBL2182387
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Cytotoxicity against human HL60R cells overexpressing Pgp incubated for 72 hrs by MTS assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL60R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Flavaglines as potent anticancer and cytoprotective agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.95 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2179713 | — | — | 1 | 8.85 |
| CHEMBL1651465 | — | — | 1 | 8.77 |
| CHEMBL2179334 | — | — | 1 | 8.66 |
| CHEMBL2179339 | — | — | 1 | 8.62 |
| CHEMBL2179340 | — | — | 1 | 8.51 |
| CHEMBL2179345 | — | — | 1 | 8.48 |
| CHEMBL556074 | — | — | 1 | 8.35 |
| CHEMBL2179715 | — | — | 1 | 8.31 |
| CHEMBL2179717 | — | — | 1 | 8.25 |
| CHEMBL2179714 | — | — | 1 | 8.15 |
| CHEMBL2179344 | — | — | 1 | 7.89 |
| CHEMBL2179343 | — | — | 1 | 7.85 |
| CHEMBL2179342 | — | — | 1 | 7.55 |
| CHEMBL2179716 | — | — | 1 | 7.38 |
| CHEMBL2179341 | — | — | 1 | 7.22 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.28 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.00 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2179713 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1651465 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2179334 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2179339 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2179340 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2179345 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL556074 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL2179715 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL2179717 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL2179714 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL2179344 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2179343 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2179342 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2179716 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2179341 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL159 | VINBLASTINE | IC50 | > | 100.0 | nM | - |