Assay Detail
Binding
CHEMBL2183722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant full length CA7 pre-incubated for 15 mins by stopped-flow CO2 hydration method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.97 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2179307 | — | — | 1 | 6.22 |
| CHEMBL2179308 | — | — | 1 | 6.21 |
| CHEMBL2179306 | — | — | 1 | 6.20 |
| CHEMBL2179305 | — | — | 1 | 6.06 |
| CHEMBL2179304 | — | — | 1 | 6.04 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.66 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2179307 | — | Ki | = | 602.0 | nM | 6.22 |
| CHEMBL2179308 | — | Ki | = | 609.0 | nM | 6.21 |
| CHEMBL2179306 | — | Ki | = | 628.0 | nM | 6.20 |
| CHEMBL2179305 | — | Ki | = | 873.0 | nM | 6.06 |
| CHEMBL2179304 | — | Ki | = | 912.0 | nM | 6.04 |
| CHEMBL118 | CELECOXIB | Ki | = | 2170.0 | nM | 5.66 |
| CHEMBL865 | VALDECOXIB | Ki | = | 3900.0 | nM | 5.41 |