Assay Detail
Binding
CHEMBL2184150
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Inhibition of human beta-glucocerebrosidase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.16 | 4.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088892 | — | — | 1 | 4.16 |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | - |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088892 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL1029 | MIGLUSTAT | IC50 | = | 399000.0 | nM | - |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 195000.0 | nM | - |