Compound Detail
CHEMBL1088892
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Basic Information
| ChEMBL ID | CHEMBL1088892 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZSNFEMNRWFDMNU-HOTMZDKISA-N |
4
Targets
11
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
219.3
MW (Da)
-1.41
ALogP
5
HBA
5
HBD
93.0
PSA (Ų)
0.40
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 11 meas. best 6.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal CHEMBL3114 | IC50 | 6.35 | 5.885 | 450.0 | 2 |
| Acidic alpha-glucosidase CHEMBL3513 | IC50 | 4.92 | 4.92 | 12000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.92 | 4.92 | 12000.0 | 1 |
| Lysosomal acid glucosylceramidase CHEMBL2179 | IC50 | 4.16 | 4.08 | 70000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal | IC50 | = | 450.0 | nM | 6.35 | Inhibition of rat intestinal isomaltase using isomaltase as substrate | 23106358 |
| Sucrase-isomaltase, intestinal | IC50 | = | 3800.0 | nM | 5.42 | Inhibition of rat intestinal sucrase using sucrose as substrate | 23106358 |
| Unchecked | IC50 | = | 12000.0 | nM | 4.92 | Inhibition of rat N-terminal maltase-glucoamylase catalytic domain | 23106358 |
| Acidic alpha-glucosidase | IC50 | = | 12000.0 | nM | 4.92 | Inhibition of rat intestinal maltase using moltose as substrate | 23106358 |
| Lysosomal acid glucosylceramidase | IC50 | = | 70000.0 | nM | 4.16 | Inhibition of human beta-glucocerebrosidase | 23106358 |
| Lysosomal acid glucosylceramidase | IC50 | = | 100000.0 | nM | 4.0 | Inhibition of human recombinant beta-glucocerebrosidase preincubated for 10 mins... | 20231099 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23106358 | 10.1021/jm301304e | Unchecked | 2 |
| 23106358 | 10.1021/jm301304e | Sucrase-isomaltase, intestinal | 2 |
| 20231099 | 10.1016/j.bmc.2010.02.027 | Lysosomal acid glucosylceramidase | 1 |
| 23106358 | 10.1021/jm301304e | Uncharacterized protein | 1 |
| 23106358 | 10.1021/jm301304e | Trehalase | 1 |
| 23106358 | 10.1021/jm301304e | Beta-galactosidase | 1 |
| 23106358 | 10.1021/jm301304e | Lactase/phlorizin hydrolase | 1 |
| 23106358 | 10.1021/jm301304e | Lysosomal acid glucosylceramidase | 1 |
| 23106358 | 10.1021/jm301304e | Glucosylceramidase | 1 |
| 23106358 | 10.1021/jm301304e | Acidic alpha-glucosidase | 1 |
Data from ChEMBL 36 via Core Engine