Assay Detail
Functional
CHEMBL2184382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human RCC4 cells expressing HIF2alpha and HIF1alpha after 2 days by XTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RCC4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.75 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380500 | VARIOLIN B | — | 1 | 5.06 |
| CHEMBL2177349 | HALICLONADIAMINE | — | 1 | 4.81 |
| CHEMBL157844 | PUUPEHENONE | — | 1 | 4.75 |
| CHEMBL2177348 | — | — | 1 | 4.58 |
| CHEMBL2177350 | NEOPETROFORMYNE A | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380500 | VARIOLIN B | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL2177349 | HALICLONADIAMINE | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL157844 | PUUPEHENONE | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2177348 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL2177350 | NEOPETROFORMYNE A | IC50 | = | 27500.0 | nM | 4.56 |