Assay Detail
Functional
CHEMBL2185069
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Cytotoxicity against human SW780 cells after 96 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.29 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.96 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.17 |
| CHEMBL2181000 | — | — | 1 | 7.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL107 | COLCHICINE | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL2181000 | — | IC50 | = | 18.8 | nM | 7.73 |