Assay Detail
Functional
CHEMBL2185077
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Cytotoxicity against human DLD1 cells after 96 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.75 | 8.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181000 | — | — | 1 | 8.79 |
| CHEMBL2180999 | — | — | 1 | 8.33 |
| CHEMBL2181008 | — | — | 1 | 7.94 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.81 |
| CHEMBL2181004 | — | — | 1 | 7.80 |
| CHEMBL2181005 | — | — | 1 | 7.51 |
| CHEMBL2181006 | — | — | 1 | 7.49 |
| CHEMBL2181001 | — | — | 1 | 7.45 |
| CHEMBL2181007 | — | — | 1 | 7.45 |
| CHEMBL2181002 | — | — | 1 | 7.44 |
| CHEMBL2181009 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181000 | — | IC50 | = | 1.61 | nM | 8.79 |
| CHEMBL2180999 | — | IC50 | = | 4.67 | nM | 8.33 |
| CHEMBL2181008 | — | IC50 | = | 11.38 | nM | 7.94 |
| CHEMBL107 | COLCHICINE | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL2181004 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL2181005 | — | IC50 | = | 31.17 | nM | 7.51 |
| CHEMBL2181006 | — | IC50 | = | 32.6 | nM | 7.49 |
| CHEMBL2181001 | — | IC50 | = | 35.2 | nM | 7.45 |
| CHEMBL2181007 | — | IC50 | = | 35.9 | nM | 7.45 |
| CHEMBL2181002 | — | IC50 | = | 36.2 | nM | 7.44 |
| CHEMBL2181009 | — | IC50 | = | 51.6 | nM | 7.29 |