Assay Detail
Binding
CHEMBL2185079
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Binding affinity to pig brain tubulin
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 9.79 | 10.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181004 | — | — | 1 | 10.34 |
| CHEMBL2181003 | — | — | 1 | 10.23 |
| CHEMBL2181002 | — | — | 1 | 10.20 |
| CHEMBL2181009 | — | — | 1 | 9.91 |
| CHEMBL2181006 | — | — | 1 | 9.90 |
| CHEMBL2181001 | — | — | 1 | 9.88 |
| CHEMBL2181000 | — | — | 1 | 9.85 |
| CHEMBL2181008 | — | — | 1 | 9.74 |
| CHEMBL2180999 | — | — | 1 | 9.70 |
| CHEMBL2181007 | — | — | 1 | 9.55 |
| CHEMBL2181005 | — | — | 1 | 9.44 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181004 | — | Ki | = | 0.04603 | nM | 10.34 |
| CHEMBL2181003 | — | Ki | = | 0.05848 | nM | 10.23 |
| CHEMBL2181002 | — | Ki | = | 0.06368 | nM | 10.20 |
| CHEMBL2181009 | — | Ki | = | 0.1219 | nM | 9.91 |
| CHEMBL2181006 | — | Ki | = | 0.1268 | nM | 9.90 |
| CHEMBL2181001 | — | Ki | = | 0.1312 | nM | 9.88 |
| CHEMBL2181000 | — | Ki | = | 0.1426 | nM | 9.85 |
| CHEMBL2181008 | — | Ki | = | 0.1832 | nM | 9.74 |
| CHEMBL2180999 | — | Ki | = | 0.1982 | nM | 9.70 |
| CHEMBL2181007 | — | Ki | = | 0.2799 | nM | 9.55 |
| CHEMBL2181005 | — | Ki | = | 0.3673 | nM | 9.44 |
| CHEMBL107 | COLCHICINE | Ki | = | 1.614 | nM | 8.79 |